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Early Stage Researcher

MARIE CURIE FELLOWSHIP OFFERED

Madrid, Spain

A PhD position is available for an Early Stage Researcher in the framework of the Marie Curie Initial Training Network DYNANO (Dynamic Interactive Nanosystems).

Summary: 36-month position at the Rocasolano Institute of Physical Chemistry (Spanish National Research Council, CSIC) for an Early Stage Researcher in the framework of the ITN DYNANO. DYNANO’s scientific objective is the design, evaluation and optimization of functional nanosystems of biomedical and biotechnological interest. Research activities at the Rocasolano Institute will be focussed on lectin-carbohydrate systems of biomedical relevance. In particular, the work to be carried out involves the development and application of new microarray platforms, from lectin to cell microarrays, and the testing of the assembling, organization and functionality of lectin/carbohydrate-bearing nanosystems, including naturally occurring extracellular vesicles (in collaboration with the Membrane Nanovesicle Research Group from the Department of Genetics of the Semmelweis University, Budapest, Hungary).

Description: Coding of bioinformation by glycans and information transfer via lectins is key to many biological and biomedical relevant processes, as bacterial and viral infections, inflammation, immune response, tumour progression and metastasis. In these processes, the lectins act as physiological sensors for specific glycan epitopes. This exquisite selectivity can be exploited for the development of biosensing approaches for e.g. detection of viruses, bacteria, and bacterial toxins, the identification of endogenous receptors for pathogens, or the analysis of the glycosylation profiles of glycoproteins, cells, or tissues, of relevance for cancer diagnostics. To this aim, a detailed knowledge of the structural features, stability, and thermodynamics of lectins and lectin-ligand interactions is also essential. The group leaded by Dr. Dolores Solís holds extensive expertise in this field, mastering the fundamentals and applications of a variety of biophysical techniques and approaches, including the microarray technology. One of the main objectives of the research activities to be carried out by the recruited researcher is the development and application of novel microarray platforms. This will include the design and development of microarrays for specific case studies (designer’ microarrays), the incorporation of a variety of sensors into microarrays (carbohydrates, glycoconjugates, lectins, pathogens, cells, etc.), and the development of new microarray strategies for the study of carbohydrate-mediated interactions, with special focus on pathogens and host-pathogen interactions. In addition, the work will involve the investigation of the structural organization and functionality of other lectin/carbohydrate-bearing nanosystems, including naturally occurring extracellular vesicles (in collaboration with the Membrane Nanovesicle Research Group, Semmelweis University, Budapest, Hungary). The researcher will also receive cross-disciplinary training in other groups within the network, holding expertises in chemistry, biology & biomedicine and industry ToK (further information on the DYNANO network is available at www.dynano.eu).

Requirements: The position is open to post graduates in chemistry, biological sciences, or related disciplines, preferably holding a Master degree or equivalent. At the time of recruitment, they must be in the first four years (full-time equivalent) of their research careers, have not yet been awarded a doctoral degree, and must not have resided or carried out their main activity (work, studies, etc) in Spain for more than 12 months in the 3 years immediately prior to the reference date. The successful candidate will be offered a full-time 36-month employment contract with full social benefits and the allowances established in the People 2011 Work programme. Detailed information on the eligibility criteria, mobility rule and yearly reference rates for allowances can be found at ftp://ftp.cordis.europa.eu/pub/fp7/docs/wp/people/ m-wp-201101_en.pdf. Candidates should send by e-mail a CV, a certificate with the disciplines of the university degree and corresponding marks, a short statement of research interest, and the names of 3 referees, to Dr. Dolores Solís (d.solis@iqfr.csic.es).

Instituto de Química Física Rocasolano

(http://www.iqfr.csic.es)

Consejo Superior de Investigaciones Científicas

Madrid, Spain

Approximate Start Date: May-June, 2012

Application Deadline: March 31, 2012