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Council for Scientific Research of Spain (CSIC)

CSIC is represented in GlycoHIT by two of its constituent bodies- the Centre for Biological Research (CIB) and the Rocasolano Institute of Physical Chemistry (IQFR).

CIB
The Centre for Biological research (CIB); is part of the Higher Council for Scientific Research  of Spain (CSIC) and is located within the Univesidad Complutense Campus in Madrid.

Prof. Jiménez-Barbero is head of the Chemical and Physical Biology (CPB) section of the CIB. Research at CPB focuses on the investigation of protein conformation, structure, dynamics, and function, as well as on the specific molecular interactions between proteins and other biomolecules and the formation of supra-molecular assemblies. Research in these topics is ideally suited towards developing a more quantitative approach to Biology. Its goal is to use the understanding of these processes for design and engineering of proteins, ligands, and macromolecular machines “a la carte” which will open new biotechnological horizons. Prof. Jiménez-Barbero’s research group has a long-standing experience and international reputation in the application of NMR methods to the study of the three dimensional structure of proteins and their complexes with carbohydrates and glycomimetics. During the past ten years, the group has focused on the study of the conformational features of the molecular recognition processes between saccharides and proteins and enzymes. Apart from NMR, the team has also access to other techniques, such as isothermal microcalometry and analytical ultracentrifugation, which may allow the deduction of other physicochemical parameters relevant to the study of intermolecular interactions.

Personnel

Prof. Jiménez-Barbero is the recent International Whistler Award in Carbohydrate Chemistry, awarded by the International Carbohydrate Organization and will organize the 2012 International Carbohydrate Symposium at Madrid.

Specialist facilities.

NMR (two 600 MHz and one 500 MHz spectrometers in situ, access to 700 and 800 MHz in Madrid, access to 750 MHz in Santiago de Compostela, access to 800 MHz in Barcelona).  MALDI, BIACORE, Isothermal Titration Microcalorimetry, Analytical Ultracentrifugation, Circular Dichroism in situ.

IQFR
Dr. Dolores Solís is the current Head of the Department of Physical Chemistry of BiologicalMacromolecules at Rocasolano Institute of Physical Chemistry (IQFR), which is also acomponent Institute of CSIC. Her group is focused on compound/target characterization andthorough analysis of intermolecular interactions, particularly of carbohydrate recognition byproteins, for rational design of carbohydrate-based drugs. This includes the study of thestructural organization and stability of protein targets, identification of the liganddeterminants essential for recognition and a thorough thermodynamic characterisation of thebinding process. To this aim, a variety of biophysical methods and techniques housed by thegroup are used, including analytical ultracentrifugation, multi-angle laser light scattering andother spectroscopic techniques (circular dichroism, fluorimetry, etc.), microcalorimetry(differential scanning and isothermal titration calorimetry), different liquid chromatographysystems, and binding/inhibition radioassays.